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. 1964 Nov;7(6):665–670.

The response of spleen cells from immunized rabbits to cross-reacting antigens, in an in vitro system*

R W Dutton, Gillian M Page
PMCID: PMC1423403  PMID: 14239841

Abstract

Rabbits were immunized with bovine (BSA) or human (HSA) serum albumin. Spleen cell suspensions were prepared and incubated with the homologous or cross-reacting albumins. The antigen-dependent stimulation of the rate of DNA synthesis was used as a measure of the antigenic activity of each of the albumin preparations. The response was proportional to the logarithm of the antigen concentration for both the homologous and the cross-reacting albumins and the slopes of each curve were approximately the same. The cross-reacting albumins were less stimulatory than the homologous antigen. The pattern of their relative activities in this system followed the same pattern shown in their serological cross-reactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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