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. 1965 May;8(5):511–518.

Oxygen consumption during histamine release by antigen and compound 48/80

J L Mongar, B A V Perera
PMCID: PMC1423480  PMID: 4158141

Abstract

The oxygen consumption of isolated rat mast cells has been determined using a micro capillary respirometer designed by Cunningham and Kirk and modified to permit stirring and addition of reactants. Uptake ranged from 0.5 pl. per cell per minute in 100 per cent O2 to 0.1 pl. per cell per minute in 1 per cent O2. It remained steady for at least 1 hour and was not affected by the presence of glucose.

Under a variety of conditions neither histamine release by antigen added to sensitized cells nor by compound 48/80 added to normal cells resulted in any increase in the rate of oxygen uptake. Oxygen does not appear to be a rate limiting factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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