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. 1965 Jan;8(1):81–87.

Electron microscopic observations on the localization of antigen in the tuberculin reaction

W Norton, M Ziff
PMCID: PMC1423520  PMID: 14245317

Abstract

The tuberculin reaction was examined in the electron microscope using as antigen PPD conjugated to ferritin. The ferritin marker was rapidly localized within macrophages prior to the time of significant lymphocyte accumulation. Evidence of degenerative changes in macrophages was seen. Uptake of marker by lymphocytes was not noted. Appropriate control experiments indicated that the uptake of antigen by macrophages and subsequent macrophage degeneration were not dependent on previous sensitization. The accumulation of lymphocytes without apparent contact with unaltered antigen was interpreted as evidence that lymphocyte accumulation was a consequence of the prior interaction between antigen and macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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