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. 1965 Jul;9(1):85–92.

Changes in mouse 7S γ-globulin resulting from immunization with transplantable tumours

D E H Tee, J Watkins, Mildred Wang, D B Gammack, J H Raper
PMCID: PMC1423556  PMID: 5838980

Abstract

The antibody response of A strain mice to immunization with C57BL mouse leukaemia, EL4, is confined to the 7S γ-globulin.

A rapid chromatographic method has been developed for the isolation of mouse 7S γ-globulin in a high state of purity as judged by immunological and electrophoretic techniques.

The apparent molecular weight (MSD) of the immune γ-globulin preparation did not differ significantly from that of the normal γ-globulin preparation.

However, weight average (MW) and Z average (MZ) molecular weights determined from sedimentation equilibrium experiments showed differences in the two preparations. The MZ/MW ratios showed that the molecular polydispersity in the immune sample was significantly greater than that in the normal sample.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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