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. 1965 Dec;9(6):501–519.

The immune response to influenza virus

I. Effect of the route and schedule of vaccination on the time course of the immune response, as measured by three serological methods

R G Webster
PMCID: PMC1423613  PMID: 5853072

Abstract

The influence of the route and schedule of vaccination on the time course of the immune response was studied in groups of rabbits injected with influenza virus antigens. The route and schedule of inoculation determined the maximal level of serum antibody. The routes can be ordered intravenous, intraperitoneal and subcutaneous in descending order of efficiency. Multiple doses improved the levels of antibody by all routes, while antigen in Freund's incomplete adjuvant suppressed the initial response. Changes in the ratios between the three tests indicated differences in avidity of antibody produced during the initial and the secondary responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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