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. 1966 Jan;10(1):21–33.

The immunogenicity of cephalosporin derivatives and their cross-reaction with penicillin

F R Batchelor, Janet M Dewdney, R D Weston, A W Wheeler
PMCID: PMC1423621  PMID: 4160334

Abstract

Cephalothin and cephaloridine, antibiotics with the 7-amino cephalosporanic acid nucleus, have been shown to form protein conjugates which were able to stimulate production of haemagglutinating, precipitating and guinea-pig skin-sensitizing antibodies in the rabbit. A high degree of cross-reaction with the benzyl penicilloyl determinant group was demonstrated, but evidence was found of only very limited cross-reaction with the haptenic determinant of the penicillin nucleus, 6-amino penicillanic acid. Cephalothin did not induce contact sensitivity in guinea-pigs. These results are discussed with particular respect to the relative parts which the side chain and nucleus of these related antibiotics play in determining antigenic specificity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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