Abstract
Attempts were made to desensitize guinea-pigs (which had been actively sensitized to bovine serum albumin) by injecting them 2 days before challenge with a near-lethal dose of the antigen under protection of antihistamine. No statistically significant desensitization occurred although there was a significant drop in the mean serum antibody titre as well as in the mean complement levels. However, antibody titre and sensitivity to anaphylaxis could not be correlated.
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Selected References
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- BENACERRAF B., OVARY Z., BLOCH K. J., FRANKLIN E. C. Properties of guinea pig 7S antibodies. I. Electrophoretic separation of two types of guinea pig 7S antibodies. J Exp Med. 1963 Jun 1;117:937–949. doi: 10.1084/jem.117.6.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLOCH K. J., KOURILSKY F. M., OVARY Z., BENACERRAF B. Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis. J Exp Med. 1963 Jun 1;117:965–981. doi: 10.1084/jem.117.6.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOREUS L. O. Quantitative studies on the anaphylactic mastcell reaction in vivo in the guinea pig. Acta Physiol Scand. 1960 Apr 25;48:431–438. doi: 10.1111/j.1748-1716.1960.tb01876.x. [DOI] [PubMed] [Google Scholar]
- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BROCKLEHURST W. E. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock. J Physiol. 1960 Jun;151:416–435. doi: 10.1113/jphysiol.1960.sp006449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bliss C. I. THE METHOD OF PROBITS--A CORRECTION. Science. 1934 May 4;79(2053):409–410. doi: 10.1126/science.79.2053.409. [DOI] [PubMed] [Google Scholar]
- Bliss C. I. THE METHOD OF PROBITS. Science. 1934 Jan 12;79(2037):38–39. doi: 10.1126/science.79.2037.38. [DOI] [PubMed] [Google Scholar]
- FINK M. A., ROTHLAUF M. V. Variations in sensitivity to anaphylaxis and to histamine in inbred strains of mice. Proc Soc Exp Biol Med. 1954 Feb;85(2):336–338. doi: 10.3181/00379727-85-20873. [DOI] [PubMed] [Google Scholar]
- FRICK O. L., HALPERN B. N., LIACOPOULOS P. The mechanism of protection from anaphylactic shock in the guinea-pig by pre-treatment with anaphylatoxin. J Physiol. 1962 Sep;163:191–199. doi: 10.1113/jphysiol.1962.sp006967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OVARY Z., BENACERRAF B., BLOCH K. J. Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis. J Exp Med. 1963 Jun 1;117:951–964. doi: 10.1084/jem.117.6.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OVARY Z., FUDENBERG H., KUNKEL H. G. Anuphylactic reactions in the skin of the guinea pig with high and low molecular weight antibodies and gamma globulins. J Exp Med. 1960 Nov 1;112:953–961. doi: 10.1084/jem.112.5.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PRUZANSKY J. J., FEINBERG S. M., KENNIEBREW A. Passive anaphylaxis in the guinea pig and its inhibition by an extraneous antigen-antibody reaction. J Immunol. 1959 Jun;82(6):497–501. [PubMed] [Google Scholar]
- ROTHBERG R., TALMAGE D. W. Circulating antibody and anaphylaxis in mice. J Immunol. 1961 Mar;86:302–306. [PubMed] [Google Scholar]
- STAVITSKY A. B. Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954 May;72(5):360–367. [PubMed] [Google Scholar]
- TREADWELL P. E., RASMUSSEN A. F., Jr PASSIVE ANAPHYLAXIS IN MICE WITH HOMOLOGOUS ANTISERUM. III. STRAIN SUSCEPTIBILITY AND MODIFICATION WITH PRIOR ANTIGEN-ANTIBODY REACTIONS. J Immunol. 1963 Dec;91:859–865. [PubMed] [Google Scholar]
- WALASZEK E. J., HUGGINS C. G., SMITH C. M. Drugs that modify actions of pharmacologically active polypeptides. Ann N Y Acad Sci. 1963 Feb 4;104:281–289. doi: 10.1111/j.1749-6632.1963.tb17673.x. [DOI] [PubMed] [Google Scholar]
- WHITE R. G., JENKINS G. C., WILKINSON P. C. The production of skin-sensitizing antibody in the guinea-pig. Int Arch Allergy Appl Immunol. 1963;22:156–165. doi: 10.1159/000229362. [DOI] [PubMed] [Google Scholar]
