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. 1966 Feb;10(2):187–191.

Evidence for a humoral thymic factor in rabbits

C A H Trench, J W Watson, F C Walker, P S Gardner, C A Green
PMCID: PMC1423644  PMID: 4160442

Abstract

Rabbits thymectomized between 12 and 36 hours after birth subsequently show reduced levels of circulating lymphocytes together with a lowered immunological response to human γ-globulin. These effects of thymectomy can, to a large extent, be prevented by means of intraperitoneal auto-transplants of thymus in a Millipore diffusion chamber. It appears possible that the epithelial-reticular cells of the transplant persist in the diffusion chamber and elaborate a humoral factor, or factors, which take part in the maturation of antibody-producing cells.

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Selected References

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