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. 1965 Nov;9(5):417–425.

Immunological studies on the rat thymectomized in adult life

H F Jeejeebhoy
PMCID: PMC1423715  PMID: 5321351

Abstract

Rats thymectomized in adult life showed no decrease in ability to produce circulating antibodies to sheep erythrocytes and tetanus toxoid even when tested 270 days after thymectomy. From 120 days after thymectomy onwards allogeneic skin-graft rejection times were increased to about twice that found in control animals.

Rabbit anti-rat lymphocyte serum (ALS) was given to non-thymectomized rats and, at varying intervals after thymectomy, to rats which had been thymectomized in adult life. Non-thymectomized rats so treated showed no decrease in their ability to reject allogeneic skin grafts or to produce antibodies to sheep erythrocytes. In contrast there was a significant depression of the immune response of all thymectomized rats given ALS. Allogeneic skin graft rejection times were longer in animals given ALS 180 and 240 days after thymectomy than in any of the other groups of animals.

There was a significant depression in the ability of animals given ALS 240 days after thymectomy to produce antibody in response to the second of two doses of tetanus toxoid injected 7 weeks after the administration of ALS. All other animals behaved normally when immunized in this way.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C., WILKES B. IMMUNOLOGIC STATUS OF THYMECTOMIZED ADULT RATS. J Immunol. 1964 Jul;93:75–80. [PubMed] [Google Scholar]
  2. FULTHORPE A. J. Tetanus antitoxin titration by haemagglutination. J Hyg (Lond) 1957 Sep;55(3):382–401. doi: 10.1017/s0022172400037293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HAMILTON L. D. Nucleic acid turnover studies in human leukaemic cells and the function of lymphocytes. Nature. 1956 Sep 15;178(4533):597–599. doi: 10.1038/178597a0. [DOI] [PubMed] [Google Scholar]
  4. LEVEY R. H., TRAININ N., LAW L. W. EVIDENCE FOR FUNCTION OF THYMIC TISSUE IN DIFFUSION CHAMBERS IMPLANTED IN NEONATALLY THYMECTOMIZED MICE. PRELIMINARY REPORT. J Natl Cancer Inst. 1963 Aug;31:199–217. [PubMed] [Google Scholar]
  5. METCALF D. The thymic origin of the plasma lymphocytosis stimulating factor. Br J Cancer. 1956 Sep;10(3):442–457. doi: 10.1038/bjc.1956.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. OSOBA D., MILLER J. F. EVIDENCE FOR A HUMORAL THYMUS FACTOR RESPONSIBLE FOR THE MATURATION OF IMMUNOLOGICAL FACULTY. Nature. 1963 Aug 17;199:653–654. doi: 10.1038/199653a0. [DOI] [PubMed] [Google Scholar]
  7. SACKS J. H., FILIPPONE D. R., HUME D. M. STUDIES OF IMMUNE DESTRUCTION OF LYMPHOID TISSUE. I. LYMPHOCYTOTOXIC EFFECT OF RABBIT-ANTI-RAT-LYMPHOCYTE ANTISERUM. Transplantation. 1964 Jan;2:60–74. doi: 10.1097/00007890-196401000-00007. [DOI] [PubMed] [Google Scholar]
  8. TERASAKI P. I., ESAIL M. L., CANNON J. A., LONGMIRE W. P., Jr Destruction of lymphocytes in vitro by normal serum from common laboratory animals. J Immunol. 1961 Oct;87:383–395. [PubMed] [Google Scholar]

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