Abstract
India ink or other finely divided agents (trypan blue, saccharated iron oxide, thorotrast, polystyrene latex) were injected intravenously into mice, and sheep erythrocyte stroma injected subsequently by the same route.
The splenic uptake of stroma carrying a tag of 131I was consistently higher in mice treated with the `blockading' agents than in untreated controls, the difference in some experiments being greater than ten-fold.
In addition to promoting the splenic uptake of antigen, some of the finely divided agents also enhanced the formation of anti-sheep red cell haemolysin in mice immunized with a single intravenous injection of sheep erythrocyte stroma.
India ink injected intravenously caused a significant rise in the splenic weight of mice.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BENACERRAF B., HALPERN B. N., BIOZZI G., BENOS S. A. Quantitative study of the granulopectic activity of the reticulo-endothelial system. III. The effect of cortisone and nitrogen mustard on the regenerative capacity of the R.E.S. after saturation with carbon. Br J Exp Pathol. 1954 Apr;35(2):97–106. [PMC free article] [PubMed] [Google Scholar]
- BENACERRAF B., HALPERN B. N., STIFFEL C., CRUCHAUD S., BIOZZI G. Phagocytose d'une fraction du sérum chauffé et iodé par le système réticulo-endothélial et comportement consécutif de ses cellules a l'égard d'autres colloïdes. Ann Inst Pasteur (Paris) 1955 Dec;89(6):601–620. [PubMed] [Google Scholar]
- BIOZZI G., BENACERRAF B., GRUMBACH F., HALPERN B. N., LEVADITI J., RIST N. Etude de l'activité granulopexique du système réticulo-endothélial au cours de l'infection tuberculeuse expérimentale de la souris. Ann Inst Pasteur (Paris) 1954 Sep;87(3):291–300. [PubMed] [Google Scholar]
- BIOZZI G., BENACERRAF B., HALPERN B. N. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity. Br J Exp Pathol. 1953 Aug;34(4):441–457. [PMC free article] [PubMed] [Google Scholar]
- BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
- FREEMAN T., GORDON A. H., HUMPHREY J. H. Distinction between catabolism of native and denatured proteins by the isolated perfused liver after carbon loading. Br J Exp Pathol. 1958 Oct;39(5):459–471. [PMC free article] [PubMed] [Google Scholar]
- GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HALBERSTAM D., SINGER J. M., ALLEN E. G. INFLUENCE OF ELECTROLYTES ON STABILITY OF 0.2 MICRON DIAMETER POLYSTYRENE LATEX PARTICLES. Proc Soc Exp Biol Med. 1965 Feb;118:319–323. doi: 10.3181/00379727-118-29831. [DOI] [PubMed] [Google Scholar]
- HALPERN B. N., BIOZZI G., BENACERRAF B., STIFFEL C. Phagocytosis of foreign red blood cells by the reticulo-endothelial system. Am J Physiol. 1957 Jun;189(3):520–526. doi: 10.1152/ajplegacy.1957.189.3.520. [DOI] [PubMed] [Google Scholar]
- HALPERN B. THE RETICULO-ENDOTHELIAL SYSTEM AND IMMUNITY. Triangle. 1964 Apr;11:174–181. [PubMed] [Google Scholar]
- HELLER J. H. Measurement of the function of the reticuloendothelium. Ann N Y Acad Sci. 1958 Sep 5;73(1):212–220. doi: 10.1111/j.1749-6632.1959.tb40801.x. [DOI] [PubMed] [Google Scholar]
- Jenkin C. R., Auzins I., Reade P. C. The synthesis of macroglobulin antibody to a bacterial antigen in mice after treatment with thorotrast. Aust J Exp Biol Med Sci. 1965 Oct;43(5):607–624. doi: 10.1038/icb.1965.46. [DOI] [PubMed] [Google Scholar]