Abstract
Adrenal cortical grafts transplanted between members of an inbred strain of mice (`isografts') are held to be successful when they empower adrenalectomized mice to subsist upon a diet low in NaCl. By this criterion, in which due allowance must be made for the hypertrophy of accessory adrenal tissue, the intramuscular implantation of adrenal cortical shavings, free from medullary tissue, is a reliable method of grafting. The intravascular injection of dissociated cortical cells, though sometimes successful, is not reliable. The testis, the anterior chamber of the eye, and the brain will also serve as sites of transplantation, though less efficiently than muscle.
Adrenal cortical grafts transplanted by the intramuscular method between members of different inbred strains of mice (`homografts') are unsuccessful. Homografts may, however, survive in the anterior chamber of the eye.
Immunological tolerance may be procured in respect of adrenal cortical tissue: adult A-line mice into which CBA splenic cells have been injected shortly after birth will accept CBA adrenal homografts as readily as they accept isografts. It is accordingly argued that all the `transplantation antigens' possessed by a mouse's adrenal cortical tissue are also possessed by its spleen.
Tolerant A-line mice subsisting upon homografts of CBA adrenal cortical tissue will die after adoptive immunization, i.e. after the injection of lymphoid cells taken from normal A-line mice which have been actively immunized against CBA tissues. It is shown that this procedure causes CBA tissue in the tolerant host to be destroyed; death is therefore attributed to an immunological `adrenalectomy'.
Adrenal homografts transplanted between mice of unrelated strains behave essentially like skin homografts. No opinion is expressed upon whether or not adrenal homografts might survive their transplantation between mice belonging to strains which, though closely related, stand far enough apart for skin homografts to fail.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BILLINGHAM R. E., BOSWELL T. Studies on the problem of corneal homografts. Proc R Soc Lond B Biol Sci. 1953 Jul 15;141(904):392–406. doi: 10.1098/rspb.1953.0049. [DOI] [PubMed] [Google Scholar]
- BILLINGHAM R. E., BRENT L. A simple method for inducing tolerance of skin homografts in mice. Transplant Bull. 1957 Apr;4(2):67–71. [PubMed] [Google Scholar]
- BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Actively acquired tolerance of foreign cells. Nature. 1953 Oct 3;172(4379):603–606. doi: 10.1038/172603a0. [DOI] [PubMed] [Google Scholar]
- BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity. Proc R Soc Lond B Biol Sci. 1954 Dec 15;143(910):58–80. doi: 10.1098/rspb.1954.0054. [DOI] [PubMed] [Google Scholar]
- BILLINGHAM R. E., PARKES A. S. Studies on the survival of homografts of skin and ovarian tissue in rats. Proc R Soc Lond B Biol Sci. 1955 May 17;143(913):550–560. doi: 10.1098/rspb.1955.0028. [DOI] [PubMed] [Google Scholar]
- DEMPSTER W. J. The transplanted adrenal gland. Br J Surg. 1955 Mar;42(175):540–552. doi: 10.1002/bjs.18004217519. [DOI] [PubMed] [Google Scholar]
- GREENE H. S. Compatibility and non-compatibility. Ann N Y Acad Sci. 1955 Jan 24;59(3):311–325. doi: 10.1111/j.1749-6632.1955.tb45942.x. [DOI] [PubMed] [Google Scholar]
- KOPROWSKI H. Actively acquired tolerance to a mouse tumour. Nature. 1955 Jun 18;175(4468):1087–1088. doi: 10.1038/1751087b0. [DOI] [PubMed] [Google Scholar]
- KROHN P. L. Ovarian homotransplantation. Ann N Y Acad Sci. 1955 Jan 24;59(3):443–447. doi: 10.1111/j.1749-6632.1955.tb45958.x. [DOI] [PubMed] [Google Scholar]
- MEDAWAR P. B., SPARROW E. M. The effects of adrenocortical hormones, adrenocorticotrophic hormone and pregnancy on skin transplantation immunity in mice. J Endocrinol. 1956 Nov;14(3):240–256. doi: 10.1677/joe.0.0140240. [DOI] [PubMed] [Google Scholar]
- MITCHISON N. A. Passive transfer of transplantation immunity. Proc R Soc Lond B Biol Sci. 1954 Feb 18;142(906):72–87. doi: 10.1098/rspb.1954.0007. [DOI] [PubMed] [Google Scholar]
- WOODRUFF M. F., SIMPSON L. O. Induction of tolerance to skin homografts in rats by injection of cells from the prospective donor soon after birth. Br J Exp Pathol. 1955 Oct;36(5):494–499. [PMC free article] [PubMed] [Google Scholar]