Abstract
Immunological tolerance can be produced in a small proportion of rats grafted at birth with foreign homologous skin. In spite of the regional origin of the antigenic stimulus provided by such a homograft, the tolerance which it produces is certainly systemic, because it extends to homografts transplanted later in life to a different part of the body. Evidence of a regional component in the tolerance produced by a skin homograft transplanted at birth was not obtained.
Extirpation of a skin homograft one month after its transplantation at birth weakens the state of tolerance that prevails two months after birth, but does not abolish it completely.
It is likely but not certain that skin homografts transplanted at birth produce tolerance of thyroid homografts transplanted from the same donors two months after birth.
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Selected References
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