Abstract
We cannot say that the intracerebral route or the intranasal route is a satisfactory method of determining the virulence of Bordetella pertussis for mice, but only that the intracerebral route determines the intracerebral virulence and the intranasal route the intranasal virulence, for these do not run hand in hand.
Toxin plays a part in the intranasal virulence by facilitating the primary lodgement of the organism in the lung, probably by paralysing the cilia of the ciliated epithelium. Toxin does not appear to play any obvious role in intracerebral virulence in which primary lodgement is mechanical.
The ability of the organism to grow in the tissue then comes into play. The factor responsible for growth in the lung does not appear to be identical with the factor responsible for growth in the brain.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barclay A. E., Franklin K. J., Macbeth R. G. A contribution to the study of ciliary movement. J Physiol. 1937 Aug 17;90(3):347–348. doi: 10.1113/jphysiol.1937.sp003519. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Norton J. F., Dingle J. H. Virulence Tests for Typhoid Bacilli and Antibody Relationships in Antityphoid Sera. Am J Public Health Nations Health. 1935 May;25(5):609–617. doi: 10.2105/ajph.25.5.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STANDFAST A. F. B. The phase I of Haemophilus pertussis. J Gen Microbiol. 1951 Aug;5(3):531–545. doi: 10.1099/00221287-5-3-531. [DOI] [PubMed] [Google Scholar]
- STANDFAST A. F. B. The virulence of Haemophilus pertussis for mice by the intranasal route. J Gen Microbiol. 1951 May;5(2):250–266. doi: 10.1099/00221287-5-2-250. [DOI] [PubMed] [Google Scholar]