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. 1958 Apr;1(2):144–156.

A Comparison of Passive Protection Tests against Intranasal and Intracerebral Challenges with Bordetella pertussis

Jean M Dolby, A F B Standfast
PMCID: PMC1423902  PMID: 13538531

Abstract

A survey of a number of rabbit antisera to Bordetella pertussis revealed the existence of two distinct antibodies, one passively protecting mice against lethal infection by the intracerebral route, the other passively protecting mice against lethal infection by the intranasal route. Neither is the antitoxin. Antisera against most, if not all, S forms of B. pertussis contain both types of protective antibody, and so to a lesser extent do B. parapertussis and B. bronchisepticus. Neither of the protective antigens is an agglutinogen, or the haemagglutinin. The two antigens can also be distinguished by active protection tests. Extensive investigations, however, had not led to an in vitro test for either of the protective antigens or their antibodies that would replace the mouse test.

The practical importance of the two distinct antigens and their antibodies is shown by the fact that assay by the intranasal and intracerebral routes of challenge will not arrange vaccines in the same order of potency either in active or in passive protection tests.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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