Abstract
By immunizing rabbits with bacteria agglutinated by corresponding immune rabbit sera group iso-precipitins were obtained. Using the iso-precipitins thus obtained the rabbit sera could be divided into two serum groups: D (a+) and D (a—); for grouping the gel diffusion technique was applied.
The serum groups are heritable; probably group D (a+) is inherited as a dominant character. D (a+) mothers can transfer Da protein non-genetically. The substance thus obtained is then gradually eliminated from the bloodstream of the young animal. Da antigen has γ-globulin electrophoretic mobility as shown by means of immunoelectrophoresis. The incidence of group D (a+) in 92 unrelated rabbits was 27.2 per cent.
The authors discuss the relationship between iso-precipitins and anti-antibodies and the practical significance of rabbit serum groups analogous to human Gm serum groups.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DUBISKI S., MILGROM F., WOZNICZKO G. A simple method of Rh determination. Nature. 1956 Sep 8;178(4532):539–539. doi: 10.1038/178539a0. [DOI] [PubMed] [Google Scholar]
- GRABAR P., WILLIAMS C. A., Jr Méthode immuno-électrophorétique d'analyse de mélanges de substances antigéniques. Biochim Biophys Acta. 1955 May;17(1):67–74. doi: 10.1016/0006-3002(55)90320-6. [DOI] [PubMed] [Google Scholar]
- GRUBB R., LAURELL A. B. Hereditary serological human serum groups. Acta Pathol Microbiol Scand. 1956;39(6):390–398. doi: 10.1111/j.1699-0463.1956.tb05067.x. [DOI] [PubMed] [Google Scholar]
- MILGROM F., DUBINSKI S. Antigenicity of antibodies of the same species. Nature. 1957 Jun 29;179(4574):1351–1352. doi: 10.1038/1791351b0. [DOI] [PubMed] [Google Scholar]
- OUDIN J. L'allotypie de certains antigènes protéidiques du sérum. C R Hebd Seances Acad Sci. 1956 May 23;242(21):2606–2608. [PubMed] [Google Scholar]
- OUDIN J. Réaction de précipitation spécifique entre des sérums d'animaux de même espèce. C R Hebd Seances Acad Sci. 1956 May 14;242(20):2489–2490. [PubMed] [Google Scholar]