Abstract
It has already been reported by one of us (Boyse, 1959) that intraperitoneal transplants of spleen cells from A strain donor mice that had been immunized against C57BL strain tissues were invariably lethal to hosts of the F1 (C57BL×A) constitution.
In this report an account is given of the pathological changes in F1 hybrid hosts that have received intravenous or intraperitoneal transplants of spleen cells from parental strain donors, with particular reference to lethal transplants. Here the outstanding features are splenomegaly, wasting, progressive histiocytosis in the spleen and lymph nodes, disappearance of lymphoid tissue, focal necrosis of the spleen and cellular infiltrations round the hepatic vessels. Following transplantation by the intraperitoneal route there are also severe pancreatic lesions associated with fat necrosis and ascites.
Differential (donor/host) cell counts of host spleen cell suspensions indicate that the spleen may be virtually replaced by donor cells, the majority of which are histiocytes. Erythropoietic function is progressively supplanted by donor tissue.
Similar, but reversible and less extensive changes occur with other (non-lethal) donor/F1-host combinations. These hosts do not waste and the proportion of donor cells included in the host spleens falls until their detection, by present methods, is no longer possible.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BILLINGHAM R. E., BRENT L. Acquired tolerance of foreign cells in newborn animals. Proc R Soc Lond B Biol Sci. 1956 Nov 13;146(922):78–90. doi: 10.1098/rspb.1956.0073. [DOI] [PubMed] [Google Scholar]
- BILLINGHAM R. E. Studies on the reaction of injected homologous lymphoid tissue cells against the host. Ann N Y Acad Sci. 1958 Oct 7;73(3):782–788. doi: 10.1111/j.1749-6632.1959.tb40857.x. [DOI] [PubMed] [Google Scholar]
- BRENT L., BROWN J., MEDAWAR P. B. Skin transplantation immunity in relation to hypersensitivity. Lancet. 1958 Sep 13;2(7046):561–564. doi: 10.1016/s0140-6736(58)90202-2. [DOI] [PubMed] [Google Scholar]
- CONGDON C. C., URSO I. S. Homologous bone marrow in the treatment of radiation injury in mice. Am J Pathol. 1957 Jul-Aug;33(4):749–767. [PMC free article] [PubMed] [Google Scholar]
- DEMPSTER W. J. Kidney homotransplantation. Br J Surg. 1953 Mar;40(163):447–465. doi: 10.1002/bjs.18004016309. [DOI] [PubMed] [Google Scholar]
- GORER P. A. Some reactions of H-2 antibodies in vitro and in vivo. Ann N Y Acad Sci. 1958 Oct 7;73(3):707–721. doi: 10.1111/j.1749-6632.1959.tb40848.x. [DOI] [PubMed] [Google Scholar]
- ILBERY P. L., KOLLER P. C., LOUTIT J. F. Immunological characteristics of radiation chimaeras. J Natl Cancer Inst. 1958 Jun;20(6):1051–1089. doi: 10.1093/jnci/20.6.1051. [DOI] [PubMed] [Google Scholar]
- SIMONSEN M., ENGELBRETH-HOLM J., JENSEN E., POULSEN H. A study of the graft-versus-host reaction in transplantation to embryos, F1 hybrids, and irradiated animals. Ann N Y Acad Sci. 1958 Oct 7;73(3):834–841. doi: 10.1111/j.1749-6632.1959.tb40863.x. [DOI] [PubMed] [Google Scholar]