Abstract
An in vitro assay procedure for evaluating the antibody response to glomerular basement membranes, lung basement membranes and tendon fibrils indicated a sharing of identical or similar antigenic components.
At least 70 per cent of the glomerular basement membrane-binding antibodies are absorbable by tendon fibrils, and eluates from such tendon preparations are not nephrotoxic.
Within the species employed (man, rabbit and dog) for glomerular basement membrane sources, there appears to be no species specificity as regards the presence of the nephrotoxic component.
Immunization of sheep with either canine or rabbit glomerular basement membrane leads to the elaboration of a haemagglutinin for the respective species.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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