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. 1961 Oct;4(4):354–365.

Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions*

E Suter, Eugenia M Kirsanow
PMCID: PMC1424134  PMID: 13918519

Abstract

In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms.

Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37Rv or Vallée.

The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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