Abstract
Immunologically immature and mature Arbor Acre White Rock fowls were splenectomized and precipitin production after a single inoculation of bovine serum albumin was assayed. Fowls splenectomized at 4, 9 or 17 weeks of age were intravenously injected at 6, 12, 20 weeks; a subcutaneous or intravenous inoculation was given to 12-week-old birds splenectomized at 8 weeks. The splenectomized animals showed a delayed antibody appearance and a later day of peak titre. Only the animals which were splenectomized at 17 weeks showed a depression. These results suggest that a greater number of immunologically competent cells are present in the spleen and that non-splenic tissue of young animals only can compensate for the removal of this organ.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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