Abstract
Comparisons of the rate of dissociation of antibody produced by recipients and donors in cell-transfer experiments were made in a BSA-anti-BSA system using the ammonium sulphate salting-out technique. It was found that: (1) antibody formed in most normal and irradiated adult recipients had dissociation rates very similar to those of the donor animals; (2) antibody formed in most newborn recipients was similar to the antibody formed in the donors with respect to the kinetics of antigen-antibody dissociation. These data were considered as evidence for the hypothesis that the recipient animal plays no direct role in the formation of antibody in cell transfer, and that the recipient environment to which the transferred cells are exposed does not appreciably affect the quality of the antibody produced.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DIXON F. J., WEIGLE W. O. The nature of the immunologic inadequacy of neonatal rabbits as revealed by cell transfer studies. J Exp Med. 1957 Jan 1;105(1):75–83. doi: 10.1084/jem.105.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
- GREY H. M. Studies on the binding between streptococcal M protein and antibody. J Exp Med. 1962 Mar 1;115:671–683. doi: 10.1084/jem.115.3.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARRIS S., HARRIS T. N., FARBER M. B. Studies on the transfer of lymph node cells. XII. The effect of anti-rabbit-leucocyte serum on the transfer of antigen-incubated lymph node cells. J Exp Med. 1958 Oct 1;108(4):411–429. doi: 10.1084/jem.108.4.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARRIS T. N., HARRIS S., BEALE H. D., SMITH J. J. Studies on the transfer of lymph node cells. IV. Effects of X-irradiation of recipient rabbits on the appearance of antibody after cell transfer. J Exp Med. 1954 Sep 1;100(3):289–300. doi: 10.1084/jem.100.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARRIS T. N., HARRIS S., FARBER M. B. Transfer of rabbit lymph node cells to neonatal recipient rabbits. J Immunol. 1962 Feb;88:199–205. [PubMed] [Google Scholar]
- ROBERTS J. C., Jr, DIXON F. J. The transfer of lymph node cells in the study of the immune response to foreign proteins. J Exp Med. 1955 Oct 1;102(4):379–392. doi: 10.1084/jem.102.4.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TALMAGE D. W., DIXON F. J., BUKANTZ S. C., DAMMIN G. J. Antigen elimination from the blood as an early manifestation of the immune response. J Immunol. 1951 Oct;67(4):243–255. [PubMed] [Google Scholar]