Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1982 Nov;14(5):691–694. doi: 10.1111/j.1365-2125.1982.tb04958.x

Variations in responses to non-steroidal anti-inflammatory drugs.

D L Scott, S Roden, T Marshall, M J Kendall
PMCID: PMC1427476  PMID: 7138748

Abstract

1 This paper assesses the variability in the response of patients with rheumatoid disease to a group of non-steroidal anti-inflammatory drugs (NSAID). 2 Thirty six patients were divided into three groups and each group received a set of four NSAID. The different drugs were each given three times daily for a week and the treatment order was randomised. 3 The study demonstrated marked variability and unpredictability in patient responses and cast doubt on the value of comparative trials of different NSAID.

Full text

PDF
691

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aylward M., Parker R. J., Holly F., Maddock J., Davies D. B. Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. Br Med J. 1975 Apr 5;2(5961):7–9. doi: 10.1136/bmj.2.5961.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Huskisson E. C., Scott J. Sulindac. Trials of a new anti-inflammatory drug. Ann Rheum Dis. 1978 Feb;37(1):89–92. doi: 10.1136/ard.37.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Huskisson E. C., Woolf D. L., Balme H. W., Scott J., Franklin S. Four new anti-inflammatory drugs: responses and variations. Br Med J. 1976 May 1;1(6017):1048–1049. doi: 10.1136/bmj.1.6017.1048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. PEARSON E. S., HARTLEY H. O. Charts of the power function for analysis of variance tests, derived from the non-central F-distribution. Biometrika. 1951 Jun;38(1-2):112–130. [PubMed] [Google Scholar]
  5. Pinals R. S., Runge L. A., Jabbs J. M., Maddi V. I. New nonsteroidal anti-inflammatory drugs. Prospective survey of relative merits. N Y State J Med. 1977 Jul;77(8):1268–1270. [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES