Abstract
1 A placebo-controlled, randomised double-blind comparison of captopril 25 mg three times a day, hydrochlorothiazide 15 mg three times a day, and the combination was conducted in 207 patients with essential hypertension with supine diastolic blood pressures of 92-110 mm Hg. Significant decreases in blood pressure were seen in all three groups; the magnitude of decrease seen with captopril and hydrochlorothiazide was similar, while the combination produced an additive response greater (p<0.001) than captopril or hydrochlorothiazide alone.
2 The major side effect reported was a rash in fewer than 6% of patients taking captopril alone or in combination. Loss of taste or proteinuria was not observed.
3 The addition of captopril to hydrochlorothiazide blunted the hypokalaemia and hyperuricaemia observed with hydrochlorothiazide alone in addition to its antihypertensive synergy. These observations indicate that this relatively low dose of captopril is safe and efficacious in the treatment of mild to moderate hypertension alone and particularly when combined with a thiazide diuretic.
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Selected References
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- Bravo E. L., Tarazi R. C. Converting enzyme inhibition with an orally active compound in hypertensive man. Hypertension. 1979 Jan-Feb;1(1):39–46. doi: 10.1161/01.hyp.1.1.39. [DOI] [PubMed] [Google Scholar]
- Case D. B., Atlas S. A., Laragh J. H., Sealey J. E., Sullivan P. A., McKinstry D. N. Clinical experience with blockade of the renin-angiotensin-aldosterone system by an oral converting-enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients. Prog Cardiovasc Dis. 1978 Nov-Dec;21(3):195–206. doi: 10.1016/0033-0620(78)90025-7. [DOI] [PubMed] [Google Scholar]
- Gavras H., Brunner H. R., Turini G. A., Kershaw G. R., Tifft C. P., Cuttelod S., Gavras I., Vukovich R. A., McKinstry D. N. Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man. N Engl J Med. 1978 May 4;298(18):991–995. doi: 10.1056/NEJM197805042981803. [DOI] [PubMed] [Google Scholar]
- Havelka J., Vetter H., Studer A., Greminger P., Lüscher T., Wollnik S., Siegenthaler W., Vetter W. Acute and chronic effects of the angiotensin-converting enzyme inhibitor captopril in severe hypertension. Am J Cardiol. 1982 Apr 21;49(6):1467–1474. doi: 10.1016/0002-9149(82)90362-9. [DOI] [PubMed] [Google Scholar]
- Raine A. E., Ledingham J. G. Clinical experience with captopril in the treatment of severe drug-resistant hypertension. Am J Cardiol. 1982 Apr 21;49(6):1475–1479. doi: 10.1016/0002-9149(82)90363-0. [DOI] [PubMed] [Google Scholar]
- Weinberger M. H. Role of sympathetic nervous system activity in the blood pressure response to long-term captopril therapy in severely hypertensive patients. Am J Cardiol. 1982 Apr 21;49(6):1542–1543. doi: 10.1016/0002-9149(82)90383-6. [DOI] [PubMed] [Google Scholar]