Abstract
Infusion of epoprostenol (prostacyclin, PGI2) in human subjects leads to a rise in pulse rate, a fall in diastolic pressure and a rise in pulse pressure. In three healthy subjects these responses to PGI2 were identical before and after 30 min continuous cigarette smoking, and demonstrate that the attenuation of the PGI2 response by smoking reported in rats does not occur in healthy humans.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boura A. L., Hui S. C., Walters W. A. Cigarette smoke inhalation specifically inhibits depressor responses to prostacyclin in the rat. Br J Pharmacol. 1981 May;73(1):3–5. doi: 10.1111/j.1476-5381.1981.tb16762.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Warrington S. J., Smith P. R., O'Grady J. Noninvasive assessment of the cardiovascular effects of prostacyclin (PGI2) in man. Eur J Cardiol. 1980;12(2):73–80. [PubMed] [Google Scholar]