Abstract
The relationship between saliva and serum paracetamol levels was investigated in ten healthy male volunteers. The salivary and serum paracetamol levels showed significant correlation with each other. The salivary and serum paracetamol concentration ratio was highly dependent on sampling time. The salivary and serum paracetamol half-lives showed significant correlation with each other while the area under curve of paracetamol concentration in saliva and serum failed to show significant correlation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Danhof M., Breimer D. D. Therapeutic drug monitoring in saliva. Clin Pharmacokinet. 1978 Jan-Feb;3(1):39–57. doi: 10.2165/00003088-197803010-00003. [DOI] [PubMed] [Google Scholar]
- Glynn J. P., Bastain W. Salivary excretion of paracetamol in man. J Pharm Pharmacol. 1973 May;25(5):420–421. doi: 10.1111/j.2042-7158.1973.tb10042.x. [DOI] [PubMed] [Google Scholar]
- Miceli J. N., Aravind M. K., Done A. K. A rapid, simple acetaminophen spectrophotometric determination. Pediatrics. 1979 Apr;63(4):609–611. [PubMed] [Google Scholar]