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. 1983 May;15(5):529–536. doi: 10.1111/j.1365-2125.1983.tb02086.x

Effect of the benzodiazepine antagonist Ro 15-1788 on flunitrazepam-induced sleep changes.

J M Gaillard, R Blois
PMCID: PMC1427719  PMID: 6134542

Abstract

1 The modifications of human sleep induced by benzodiazepines, and particularly by flunitrazepam, are complex. Stage 4 and paradoxical sleep are both decreased; however, these two effects have a different evolution during and after single or short-term drug administration. 2 The benzodiazepine antagonist Ro 15-1788 also tends to depress stage 4, but with immediate recovery in the post-drug night, and does not modify paradoxical sleep. 3 In combined administration, this drug totally reverses the hypnogenic effect of flunitrazepam, as well as its effect on paradoxical sleep but not the decrease of slow wave sleep. 4 Some of the benzodiazepine-induced alterations of sleep may be related to receptors different from central benzodiazepine receptors, or to mechanisms not directly connected to this type of receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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