Abstract
The antihypertensive drug labetalol was administered orally and intravenously to ten hypertensive patients aged between 28 and 75 years. There was a significant increase with age in both bioavailability and half-life of labetalol. Clearance tended to be lower in the elderly subjects. First pass metabolism results in variable oral bioavailability of labetalol which is greater in the elderly and this should be borne in mind when using the drug in this age group.
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Selected References
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- Breckenridge A. M., Macnee C. M., Orme N. L., Richards D. A., Sterlin M. J. Rate of onset of hypotensive response with oral labetalol [proceedings]. Br J Clin Pharmacol. 1977 Jun;4(3):388P–388P. doi: 10.1111/j.1365-2125.1977.tb00736.x. [DOI] [PubMed] [Google Scholar]
- George C. F. Drug kinetics and hepatic blood flow. Clin Pharmacokinet. 1979 Nov-Dec;4(6):433–448. doi: 10.2165/00003088-197904060-00003. [DOI] [PubMed] [Google Scholar]
- Kelly J. G., McGarry K., O'Malley K. Radioreceptor assay for labetalol. Br J Clin Pharmacol. 1981 Aug;12(2):258–260. doi: 10.1111/j.1365-2125.1981.tb01214.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McNeil J. J., Anderson A. E., Louis W. J., Morgan D. J. Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects. Br J Clin Pharmacol. 1979;8(Suppl 2):157S–161S. [PMC free article] [PubMed] [Google Scholar]
- Nies A. S., Shand D. G., Wilkinson G. R. Altered hepatic blood flow and drug disposition. Clin Pharmacokinet. 1976;1(2):135–155. doi: 10.2165/00003088-197601020-00005. [DOI] [PubMed] [Google Scholar]