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. 1982 Aug;14(2):213–217. doi: 10.1111/j.1365-2125.1982.tb01964.x

Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man.

D P Maudgal, J D Maxwell, L J Lees, R N Wild
PMCID: PMC1427740  PMID: 6285946

Abstract

1 Plasma and biliary concentrations of amoxycillin and ceftriaxone were measured after bolus intravenous administration (500 mg) in four subjects with normal hepato-biliary and renal function. 2 The mean plasma elimination half-life for ceftriaxone (t 1/2 = 330 +/- 30 min) was considerably longer than that for amoxycillin (t 1/2 = 60 +/- 9 min). 3 The biliary concentration of ceftriaxone was above plasma concentration of the drug throughout the study period, whereas amoxycillin concentration in the bile was lower than that in plasma. 4 Both plasma and biliary concentrations of ceftriaxone were substantially higher than previously determined minimum inhibitory concentration (MIC) values for E. coli (and several other common biliary tract pathogens) for over 6 h following drug administration. Amoxycillin concentration in plasma fell below MIC by 2 h, and did not reach inhibitory concentrations in bile.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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