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. 1983 Mar;15(3):380–382. doi: 10.1111/j.1365-2125.1983.tb01515.x

Kinetics of oral trifluoperazine disposition in man.

K K Midha, E D Korchinski, R K Verbeeck, R M Roscoe, E M Hawes, J K Cooper, G McKay
PMCID: PMC1427786  PMID: 6849769

Abstract

The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC-MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range 0.53-3.09 ng ml-1) and were reached 2.8 +/- 0.5 h following ingestion of the TFP tablet. The apparent terminal elimination half-life of TFP was 12.5 +/- 1.4 h. The area under the plasma concentration-time curve differed widely between subjects (range: 5.9-17.6 ng ml-1 h) suggesting large individual differences in the extent of presystemic TFP elimination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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