Abstract
1 Blood samples were taken from 30 outpatients for serum digoxin analysis before and after 5 min-4 h of rest in the supine position. 2 The digoxin concentration increased significantly during rest and a steady-state concentration was reached after approximately 2 h of rest. 3 The mean increase in serum digoxin after 2 h of rest was 23% with a considerable range, i.e. 0-75% (0-0.6 nmol/l). 4 On the analogy of a previous finding of a decrease in serum digoxin concentration during exercise in healthy subjects ingesting digoxin, the present results suggest that everyday physical activity affects the serum digoxin concentration. Standardized rest in the supine position prior to collecting blood samples from outpatients is therefore necessary for reliable serum digoxin determinations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Belz G. G., Aust P. E., Munkes R. Digoxin plasma concentrations and nifedipine. Lancet. 1981 Apr 11;1(8224):844–845. doi: 10.1016/s0140-6736(81)92727-6. [DOI] [PubMed] [Google Scholar]
- Ekelund L. G., Eklund B., Kaijser L. Time course for the change in hemoglobin concentration with change in posture. Acta Med Scand. 1971 Oct;190(4):335–336. doi: 10.1111/j.0954-6820.1971.tb07438.x. [DOI] [PubMed] [Google Scholar]
- Iisalo E. Clinical pharmacokinetics of digoxin. Clin Pharmacokinet. 1977 Jan-Feb;2(1):1–16. doi: 10.2165/00003088-197702010-00001. [DOI] [PubMed] [Google Scholar]
- Kirsch K., Kober G., Eckert P. Das Blutvolumen und die Blutvolumenverteilung vor und nach körperlicher Arbeit. Z Kreislaufforsch. 1968 Oct;57(10):969–978. [PubMed] [Google Scholar]
- Klein H. O., Lang R., Di Segni E., Kaplinsky E. Verapamil-digoxin interaction. N Engl J Med. 1980 Jul 17;303(3):160–160. doi: 10.1056/NEJM198007173030316. [DOI] [PubMed] [Google Scholar]
- Sheiner L. B., Rosenberg B., Marathe V. V., Peck C. Differences in serum digoxin concentrations between outpatients and inpatients: an effect of compliance? Clin Pharmacol Ther. 1974 Mar;15(3):239–246. doi: 10.1002/cpt1974153239. [DOI] [PubMed] [Google Scholar]
- Smith T. W., Butler V. P., Jr, Haber E. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. N Engl J Med. 1969 Nov 27;281(22):1212–1216. doi: 10.1056/NEJM196911272812203. [DOI] [PubMed] [Google Scholar]