Abstract
The effect of inhibition of prostaglandin synthesis on the systemic clearance of indocyanine green and antipyrine was studied in seven subjects. Antipyrine clearance was not altered by indomethacin suggesting that oxidative metabolism was not affected. Both aspirin and indomethacin decreased the clearance of indocyanine green presumably by reducing liver blood flow. These results suggest that an effect of inhibitors of prostaglandin synthesis on hepatic drug clearance is likely to be confined to high clearance drugs when given systemically.
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Selected References
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- CAESAR J., SHALDON S., CHIANDUSSI L., GUEVARA L., SHERLOCK S. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci. 1961 Aug;21:43–57. [PubMed] [Google Scholar]
- Gerber J. G., Nies A. S. The hemodynamic effects of prostaglandins in the rat. Evidence for important species variation in renovascular responses. Circ Res. 1979 Mar;44(3):406–410. doi: 10.1161/01.res.44.3.406. [DOI] [PubMed] [Google Scholar]
- Gerkens J. F., Shand D. G., Flexner C., Nies A. S., Oates J. A., Data J. L. Effect of indomethacin and aspirin on gastric blood flow and acid secretion. J Pharmacol Exp Ther. 1977 Dec;203(3):646–652. [PubMed] [Google Scholar]
- Kupfer D. Endogenous substrates of monooxygenases: fatty acids and prostaglandins. Pharmacol Ther. 1980;11(3):469–496. doi: 10.1016/0163-7258(80)90038-8. [DOI] [PubMed] [Google Scholar]
- Weiner M. The kinetics of inhibition of hepatic drug metabolism by prostaglandins in rabbits. Res Commun Chem Pathol Pharmacol. 1980 Sep;29(3):561–571. [PubMed] [Google Scholar]
- Wilkinson G. R., Shand D. G. Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther. 1975 Oct;18(4):377–390. doi: 10.1002/cpt1975184377. [DOI] [PubMed] [Google Scholar]
- Wood A. J., Vestal R. E., Wilkinson G. R., Branch R. A., Shand D. G. Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination. Clin Pharmacol Ther. 1979 Jul;26(1):16–20. doi: 10.1002/cpt197926116. [DOI] [PubMed] [Google Scholar]