Abstract
1 The pharmacokinetics of mianserin hydrochloride have been determined in eight normal healthy volunteers, mean age 27, and 14 elderly patients, mean age 76.
2 Mianserin was administered to volunteers by intravenous infusion (0.011 mg/kg/min for 15 min) and, on another occasion, by mouth, in a single dose of 30 mg. Elderly patients received a single oral dose of 40-60 mg.
3 The terminal elimination half-life was significantly prolonged in the elderly. In young subjects it was 9.6±1.9 (s.d.) h. In the elderly it was 27 ± 13.1 (s.d.) h.
4 Apparent oral clearance was significantly reduced in the elderly. In young subjects it was 87.1 ± 32 (s.d.) h. In the elderly, it was 38.1 ± 14.8 (s.d.) h.
5 These kinetic differences may have an important bearing on the sedative effects of mianserin.
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Selected References
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