Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1983;15(Suppl 2):227S–231S. doi: 10.1111/j.1365-2125.1983.tb05870.x

A double-blind comparative trial with mianserin and amitriptyline in outpatients with major depressive disorders

John P Feighner, Robert S Jacobs, Ronald E Jackson, Gordon Hendrickson, Charles H Merideth, Patrick D O'Meara
PMCID: PMC1427892  PMID: 6337610

Abstract

1 A double-blind trial with parallel treatment groups was conducted to compare the safety and efficacy of mianserin with amitriptyline.

2 This was a six week trial with weekly visits. Measurements at each visit included: 21 item Hamilton Depression (HAMD) Scale, Clinical Global Impression (CGI) Scale and Treatment Emergent Symptom Scale (TESS).

3 Mianserin and amitriptyline were comparable with respect to efficacy.

4 More adverse experiences were reported by amitriptyline patients. The predominant amitriptyline adverse experiences were of the anticholinergic type; the predominant mianserin adverse experience was drowsiness/fatigue.

5 The Efficacy Index (EI), a scale combining efficacy and adverse experiences, clearly demonstrated the superiority of mianserin over amitriptyline.

Full text

PDF
227S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burgess C. D., Turner P., Wadsworth J. Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs. Br J Clin Pharmacol. 1978;5 (Suppl 1):21S–28S. [PMC free article] [PubMed] [Google Scholar]
  2. Coppen A., Gupta R., Montgomery S., Ghose K., Bailey J., Burns B., de Ridder J. J. Mianserin hydrochloride: a novel antidepressant. Br J Psychiatry. 1976 Oct;129:342–345. doi: 10.1192/bjp.129.4.342. [DOI] [PubMed] [Google Scholar]
  3. Coppen A., Kopera H. Workshop on the clinical pharmacology and efficacy of mianserin. Br J Clin Pharmacol. 1978;5 (Suppl 1):91S–99S. [PMC free article] [PubMed] [Google Scholar]
  4. Daly R. J., Browne P. J., Morgan E. Mianserin in the treatment of depressive illness: a comparison with amitriptyline. Ir J Med Sci. 1979 Apr;148(4):145–148. [PubMed] [Google Scholar]
  5. Hoc J. Etude clinique comparative en double insu de la mianserine et de la nortriptyline. Acta Psychiatr Belg. 1978 Sep-Oct;78(5):833–840. [PubMed] [Google Scholar]
  6. Kopera H., Schenk H. Antidepressiva und Kardiotoxizität. Beobachtungen mit Mianserin. Dtsch Med Wochenschr. 1978 Sep 1;103(35):1373–1376. doi: 10.1055/s-0028-1129266. [DOI] [PubMed] [Google Scholar]
  7. Kopera H., Schenk H., Stulemeijer S. Phenprocoumon requirement, whole blood coagulation time, bleeding time and plasma gamma-GT in patients receiving mianserin. Eur J Clin Pharmacol. 1978 Jul 30;13(5):351–356. doi: 10.1007/BF00644608. [DOI] [PubMed] [Google Scholar]
  8. Magnus R. V. Mianserin--a study of different dosage regimes in psychiatric outpatients. Br J Clin Pract. 1979 Sep;33(9):251–258. [PubMed] [Google Scholar]
  9. Montgomery S., McAuley R., Montgomery D. B. Relationship between mianserin plasma levels and antidepressant effect in a double-blind trial comparing a single night-time and divided daily dose regimens. Br J Clin Pharmacol. 1978;5 (Suppl 1):71S–76S. [PMC free article] [PubMed] [Google Scholar]
  10. Murphy J. E., Donald J. F., Molla A. L. Mianserin in the treatment of depression in general practice. Practitioner. 1976 Jul;217(1297):135–138. [PubMed] [Google Scholar]
  11. Peet M., Tienari P., Jaskari M. O. A comparison of the cardiac effects of mianserin and amitriptyline in man. Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):309–312. doi: 10.1055/s-0028-1094554. [DOI] [PubMed] [Google Scholar]
  12. Pichot P., Dreyfus J. F., Pull C. A double-blind multicentre trial comparing mianserin with imipramine. Br J Clin Pharmacol. 1978;5 (Suppl 1):87S–90S. [PMC free article] [PubMed] [Google Scholar]
  13. Reardon J. A., Stockman A., Darlington L. G., Scott J. T. Double-blind trial of feprazone and phenylbutazone in acute gout. Curr Med Res Opin. 1980;6(7):445–448. doi: 10.1185/03007998009109465. [DOI] [PubMed] [Google Scholar]
  14. Vogel H. P., Bente D., Feder J., Helmchen H., Müller-Oerlinghausen B., Bohacek N., Mihovilović M., Brändli A., Fleischhauer J., Walcher W. Mianserin versus amitriptyline. A double-blind-trial evaluated by the AMP system. Int Pharmacopsychiatry. 1976;11(1):25–31. [PubMed] [Google Scholar]
  15. Wheatley D. Controlled clinical trial of a new antidepressant (Org. GB 94) of novel chemical formulation. Curr Ther Res Clin Exp. 1975 Dec;18(6):849–854. [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES