Abstract
Forty-one patients completed a randomized, double-blind, between-group comparison of a combination of penbutolol and frusemide, with penbutolol alone, and frusemide alone in the management of mild to moderate essential hypertension. The results suggest that the combination caused a superior reduction in systolic and diastolic pressure compared with penbutolol and a superior reduction in systolic blood pressure compared with frusemide.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Armitage P. The role of randomization in clinical trials. Stat Med. 1982 Oct-Dec;1(4):345–352. doi: 10.1002/sim.4780010412. [DOI] [PubMed] [Google Scholar]
- Baber N. S., Dawes P. M. Beta-adrenoceptor blocking drugs and diuretics in hypertension. Br J Clin Pharmacol. 1979 Apr;7(4):404–405. doi: 10.1111/j.1365-2125.1979.tb00954.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garbus S. B., Weber M. A., Priest R. T., Brewer D. D., Hubbell F. A. The abrupt discontinuation of antihypertensive treatment. J Clin Pharmacol. 1979 Aug-Sep;19(8-9):476–486. doi: 10.1002/j.1552-4604.1979.tb02510.x. [DOI] [PubMed] [Google Scholar]
- Lameijer L. D., Voermans L. A., Houtzagers J. J., Chadha D. R. Use of fixed doses of beta blocking drugs in the treatment of hypertension. Randomised study of atenolol and penbutolol. Eur J Clin Pharmacol. 1981;21(2):93–96. doi: 10.1007/BF00637507. [DOI] [PubMed] [Google Scholar]
- Meyer B. H., Müller F. O., Hundt H. K., Grigoleit H. G., Hajdu P., Heptner W. Penbutolol and furosemide in a fixed-dose combination-bio-equivalence of two formulations. S Afr Med J. 1981 Jun 13;59(25):891–893. [PubMed] [Google Scholar]
- Rangno R. E., Langlois S., Lutterodt A. Metoprolol withdrawal phenomena: mechanism and prevention. Clin Pharmacol Ther. 1982 Jan;31(1):8–15. doi: 10.1038/clpt.1982.2. [DOI] [PubMed] [Google Scholar]
- Vander Elst E., Dombey S. L., Lawrence J., Vlassak W. Controlled comparison of the effects of furosemide and hydrochlorothiazide added to propranolol in the treatment of hypertension. Am Heart J. 1981 Oct;102(4):734–740. doi: 10.1016/0002-8703(81)90099-5. [DOI] [PubMed] [Google Scholar]