Abstract
1 Fifty-nine hospitalized patients participated in a double-blind study: 19 received 15 mg midazolam, 20 received 50 mg oxazepam, and 20 placebo. The three groups were comparable with regard to age, sex, height, weight, and degree and type of insomnia.
2 The sleep-onset latency was shorter with midazolam than with placebo or oxazepam (Mann-Whitney test, α < 0.05).
3 With regard to total sleep duration and the number of nocturnal awakenings, there was no difference between the midazolam and oxazepam groups, whereas there was a difference between these two groups and placebo.
4 More subjects of the midazolam group felt calm and refreshed on awakening.
5 Safety, assessed by clinical examination and laboratory tests, was excellent.
6 This study confirms the usefulness of midazolam in treating `early' insomnia, i.e. difficulty in falling asleep.
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Selected References
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