Abstract
1 The effects of midazolam (15 and 30 mg p.o.) on the sleep of insomniac patients were assessed by means of polysomnographic recordings.
2 As compared with placebo, 15 mg midazolam significantly increased non-REM sleep while other objective measures of insomnia were only slightly modified.
3 At the 30 mg dose, midazolam significantly decreased total wake time and wake time after sleep onset. On the other hand, total sleep and non-REM sleep time were increased.
4 No development of tolerance was observed following 2 weeks of drug use.
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Selected References
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- Monti J. M., Debellis J., Gratadoux E., Alterwain P., Altier H., D'Angelo L. Sleep laboratory study of the effects of midazolam in insomniac patients. Eur J Clin Pharmacol. 1982;21(6):479–484. doi: 10.1007/BF00542042. [DOI] [PubMed] [Google Scholar]