Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1983;16(Suppl 1):103S–108S. doi: 10.1111/j.1365-2125.1983.tb02279.x

Effect of midazolam on sleep of insomniacs

G W Vogel, F Vogel
PMCID: PMC1428087  PMID: 6138060

Abstract

1 We studied in a sleep laboratory the effects of bedtime 15 mg midazolam and 20 mg midazolam on the sleep and morning performance of healthy subjects with polygraphically verified sleep onset insomnia.

2 Six subjects received 15 mg midazolam and six subjects received 20 mg midazolam for 14 consecutive nights which were preceded by a three-night placebo baseline and followed by a three-night placebo period. The medications were administered in a double-blind manner.

3 The results were that both doses increased total sleep time, reduced sleep latency, reduced wake time after sleep onset and reduced the number of awakenings. There was no difference between the doses. Midazolam had its main effect by decreasing wake time in the first third of the night.

4 We found no evidence of tolerance, drug withdrawal rebound insomnia, or drug-induced morning performance decrements. We did find evidence of an anterograde amnesia produced by the drug.

Full text

PDF
103S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Kales A., Scharf M. B., Kales J. D. Rebound insomnia: a new clinical syndrome. Science. 1978 Sep 15;201(4360):1039–1041. doi: 10.1126/science.684426. [DOI] [PubMed] [Google Scholar]
  2. Oswald I., Adam K., Borrow S., Idzikowski C. The effects of two hypnotics on sleep, subjective feelings and skilled performance. Adv Biosci. 1978 Jul 24;21:51–63. [PubMed] [Google Scholar]
  3. Pieri L., Schaffner R., Scherschlicht R., Polc P., Sepinwall J., Davidson A., Möhler H., Cumin R., Da Prada M., Burkard W. P. Pharmacology of midazolam. Arzneimittelforschung. 1981;31(12A):2180–2201. [PubMed] [Google Scholar]
  4. Roth T., Hartse K. M., Saab P. G., Piccione P. M., Kramer M. The effects of flurazepam, lorazepam, and triazolam on sleep and memory. Psychopharmacology (Berl) 1980;70(3):231–237. doi: 10.1007/BF00427879. [DOI] [PubMed] [Google Scholar]
  5. Vogel G. W., Barker K., Gibbons P., Thurmond A. A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs. Psychopharmacology (Berl) 1976 May 5;47(1):81–86. doi: 10.1007/BF00428706. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES