Abstract
1 The hypnotic efficacy and the effect on the condition after morning awakening of midazolam 15 mg and of triazolam 0.5 mg were studied in a multicentre, double-blind cross-over study in 198 out-patients with sleeping difficulties of various origin.
2 The subjects received each drug for two consecutive nights, and completed a questionnaire each day on awakening.
3 Both midazolam and triazolam significantly shortened the sleep-onset latency, reduced the number of awakenings, and increased the total sleep time.
4 The state on awakening was also significantly improved after both compounds for several self-rated items. There was a difference only with regard to the patients' feeling of being under drug influence, which was reported as being significantly more marked after triazolam.
5 In conclusion, both compounds were effective and well tolerated in the doses used, only a few side-effects being reported.
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Selected References
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