Abstract
1 Twelve healthy volunteers each received acute doses of placebo and .5, 10, 15 and 20 mg of midazolam. Seven subjects were tested before and 1, 4 and 7 h after treatment. Five subjects were given the same five treatments nocturnally and tested the following morning, 10-12 h after treatment.
2 Tests on various measures of sedation (choice reaction time and critical flicker fusion) and of drowsiness (line analogue rating scales) showed midazolam at 15 and 20 mg dose levels to be a potent sedative agent.
3 The present results suggest that the activity of midazolam is at a maximum 1 h after ingestion and that the effects of the drug have dissipated 7 h after treatment.
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Selected References
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- Hindmarch I. A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour. Arzneimittelforschung. 1975 Nov;25(11):1836–1839. [PubMed] [Google Scholar]
- Hindmarch I., Parrott A. C. Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. Br J Clin Pharmacol. 1977;4(Suppl 2):167S–173S. doi: 10.1111/j.1365-2125.1977.tb05747.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hindmarch I., Parrott A. C. The effect of a sub-chronic administration of three dose levels of a 1,5-benzodiazepine derivative, clobazam, on subjective assessments of sleep and aspects of psychomotor performance the morning following night time medication. Arzneimittelforschung. 1978;28(11):2169–2172. [PubMed] [Google Scholar]
- Parrott A. C., Hindmarch I. Factor analysis of a sleep evaluation questionnaire. Psychol Med. 1978 May;8(2):325–329. doi: 10.1017/s0033291700014379. [DOI] [PubMed] [Google Scholar]
- Parrott A. C., Hindmarch I. The Leeds Sleep Evaluation Questionnaire in psychopharmacological investigations - a review. Psychopharmacology (Berl) 1980;71(2):173–179. doi: 10.1007/BF00434408. [DOI] [PubMed] [Google Scholar]