Abstract
1 Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo.
2 Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time and reading errors were not impaired with brotizolam.
3 There were residual effects with 30 mg flurazepam. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time, and reading errors were impaired compared with placebo and 0.25 mg brotizolam.
4 Subjective assessments of performance correlated with measured performance. There was a decrease with flurazepam (visuo-motor coordination and visuo-mental processing time) compared with placebo.
Keywords: flurazepam, brotizolam, residual effects, psychomotor performance
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Jones D. M., Lewis M. J., Spriggs T. L. The effects of low doses of diazepam on human performance in group administered tasks. Br J Clin Pharmacol. 1978 Oct;6(4):333–337. doi: 10.1111/j.1365-2125.1978.tb00860.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kubicki S. Elektroenzephalographische Dosis- und Schlafprofilbeurteilung eines Hypnotikums aus der Reihe der Triazolothienodiazepine. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1979 Jun;10(2):95–100. [PubMed] [Google Scholar]
- Nicholson A. N., Stone B. M., Pascoe P. A. Studies on sleep and performance with a triazolo-1, 4-thienodiazepine (brotizolam). Br J Clin Pharmacol. 1980 Jul;10(1):75–81. doi: 10.1111/j.1365-2125.1980.tb00504.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saletu B., Grünberger J., Volavka J., Berner P. Classification and bioavailability studies with WE 941 by quantitative pharmaco-EEG and clinical analyses. Arzneimittelforschung. 1979;29(4):700–704. [PubMed] [Google Scholar]
- von Zerssen D., Koeller D. M., Rey E. R. Die Befindlichkeits-Skala (B-S)--ein einfaches Instrument zur Objektivierung von Befindlichkeitsstörungen, insbesondere im Rahmen von Längsschnittuntersuchungen. Arzneimittelforschung. 1970 Jul;20(7):915–918. [PubMed] [Google Scholar]