Abstract
1 Efficacy of and tolerance to 0.25 mg brotizolan and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties.
2 Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good-to-satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.
Keywords: brolizolam, triazolam, tolerance efficacy, hypnotic insomnia
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Selected References
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- Ahmad F., Rittmeyer P., Goetzke E., Köster J. Brotizolam as a pre-operative hypnotic. Br J Clin Pharmacol. 1983;16 (Suppl 2):419S–423S. doi: 10.1111/j.1365-2125.1983.tb02322.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bechtel W. D. Pharmacokinetics and metabolism of brotizolam in animals. Br J Clin Pharmacol. 1983;16 (Suppl 2):261S–266S. doi: 10.1111/j.1365-2125.1983.tb02298.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eberts F. S., Jr, Philopoulos Y., Reineke L. M., Vliek R. W. Triazolam disposition. Clin Pharmacol Ther. 1981 Jan;29(1):81–93. doi: 10.1038/clpt.1981.14. [DOI] [PubMed] [Google Scholar]
- Goetzke E., Findeisen P., Welbers I. B. Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam. Br J Clin Pharmacol. 1983;16 (Suppl 2):397S–401S. doi: 10.1111/j.1365-2125.1983.tb02316.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenblatt D. J., Allen M. D., Harmatz J. S., Shader R. I. Diazepam disposition determinants. Clin Pharmacol Ther. 1980 Mar;27(3):301–312. doi: 10.1038/clpt.1980.40. [DOI] [PubMed] [Google Scholar]
- Jochemsen R., Wesselman J. G., van Boxtel C. J., Hermans J., Breimer D. D. Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects. Br J Clin Pharmacol. 1983;16 (Suppl 2):291S–297S. doi: 10.1111/j.1365-2125.1983.tb02303.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuhn F. J., Böke-Kuhn K., Danneberg P., Lehr E., Stockhaus K. Pharmacology and hypnogenic properties of brotizolam in animals. Br J Clin Pharmacol. 1983;16 (Suppl 2):253S–260S. doi: 10.1111/j.1365-2125.1983.tb02297.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Velasco M., Velasco F., Cepeda C., Romo R., Pérez-Toledo M. A. Effect of a new thienodiazepine (We-941) on sleep patterns of normal and insomniac subjects. Neuropharmacology. 1981 May;20(5):461–468. doi: 10.1016/0028-3908(81)90178-7. [DOI] [PubMed] [Google Scholar]