Abstract
1 Effect of 0.25 mg brotizolam on patients with chronic obstructive lung disease of moderate to severe degree was studied.
2 There was no difference between the slopes of ventilation vs alveolar CO2 for brotizolam and placebo as compared with base line values. Mouth-occlusion pressures did not change under the influence of drug or placebo.
3 Brotizolam (0.25 mg) is without adverse side-effects on respiratory centre output or on mechanics of ventilation.
Keywords: brotizolam, hypercapnia, chronic obstructive pulmonary disease
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coccagna G., Lugaresi E. Arterial blood gases and pulmonary and systemic arterial pressure during sleep in chronic obstructive pulmonary disease. Sleep. 1978 Winter;1(2):117–124. doi: 10.1093/sleep/1.2.117. [DOI] [PubMed] [Google Scholar]
- Douglas N. J., Calverley P. M., Leggett R. J., Brash H. M., Flenley D. C., Brezinova V. Transient hypoxaemia during sleep in chronic bronchitis and emphysema. Lancet. 1979 Jan 6;1(8106):1–4. doi: 10.1016/s0140-6736(79)90451-3. [DOI] [PubMed] [Google Scholar]
- Read D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1967 Feb;16(1):20–32. doi: 10.1111/imj.1967.16.1.20. [DOI] [PubMed] [Google Scholar]
- Remmers J. E., Anch A. M., deGroot W. J. Respiratory disturbances during sleep. Clin Chest Med. 1980 Jan;1(1):57–71. [PubMed] [Google Scholar]
- Sybrecht G. W., Taubner E. M., Böhm M. M., Fabel H. Mechanical properties of the respiratory system and mouth-occlusion pressure in patients acutely intoxicated with hypnotics. Lung. 1979;156(1):49–61. doi: 10.1007/BF02713991. [DOI] [PubMed] [Google Scholar]
- Tirlapur V. G., Mir M. A. Nocturnal hypoxemia and associated electrocardiographic changes in patients with chronic obstructive airways disease. N Engl J Med. 1982 Jan 21;306(3):125–130. doi: 10.1056/NEJM198201213060301. [DOI] [PubMed] [Google Scholar]
- Whitelaw W. A., Derenne J. P., Milic-Emili J. Occlusion pressure as a measure of respiratory center output in conscious man. Respir Physiol. 1975 Mar;23(2):181–199. doi: 10.1016/0034-5687(75)90059-6. [DOI] [PubMed] [Google Scholar]