Abstract
Sodium cromoglycate was given by both intravenous injection and local intra-arterial infusion to healthy volunteers. Intravenous injection of a dose of 4 mg in four subjects caused a statistically significant rise in blood pressure and pulse rate associated with a feeling of warmth in the perineum and blush areas of the face and chest. Brachial artery infusion of sodium cromoglycate at doses of 100-1000 microgram/min caused a feeling of warmth in the limb during 26 out of 30 infusions and this sensation was subject to tachyphylaxis. During eight infusions in which there was a sensation of warmth there was no change in local blood flow as measured by strain-gauge plethysmography. In a further six studies involving 12 infusions of sodium cromoglycate the feeling of warmth was not accompanied by a rise in local skin temperature. The results suggest that sodium cromoglycate may stimulate afferent nerves in man.
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Selected References
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- Cox J. S., Beach J. E., Blair A. M., Clarke A. J., King J., Lee T. B., Loveday D. E., Moss G. F., Orr T. S., Ritchie J. T. Disodium cromoglycate (Intal). Adv Drug Res. 1970;5:115–196. [PubMed] [Google Scholar]
- Davies S. E. Effect of disodium cromoglycate on exercise-induced asthma. Br Med J. 1968 Sep 7;3(5618):593–594. doi: 10.1136/bmj.3.5618.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dixon M., Jackson D. M., Richards I. M. The action of sodium cromoglycate on 'C' fibre endings in the dog lung. Br J Pharmacol. 1980 Sep;70(1):11–13. doi: 10.1111/j.1476-5381.1980.tb10898.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dixon M., Jackson D. M., Richards I. M. The effects of sodium cromoglycate on lung irritant receptors and left ventricular cardiac receptors in the anaesthetized dog. Br J Pharmacol. 1979 Dec;67(4):569–574. doi: 10.1111/j.1476-5381.1979.tb08703.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fanta C. H., McFadden E. R., Jr, Ingram R. H., Jr Effects of cromolyn sodium on the response to respiratory heat loss in normal subjects. Am Rev Respir Dis. 1981 Feb;123(2):161–164. doi: 10.1164/arrd.1981.123.2.161. [DOI] [PubMed] [Google Scholar]
- Russell J. A., Lai-Fook S. J. Reflex bronchoconstriction induced by capsaicin in the dog. J Appl Physiol Respir Environ Exerc Physiol. 1979 Nov;47(5):961–967. doi: 10.1152/jappl.1979.47.5.961. [DOI] [PubMed] [Google Scholar]
- Walker S. R., Evans M. E., Richards A. J., Paterson J. W. The fate of ( 14 C)disodium cromoglycate in man. J Pharm Pharmacol. 1972 Jul;24(7):525–531. doi: 10.1111/j.2042-7158.1972.tb09051.x. [DOI] [PubMed] [Google Scholar]