Abstract
Ten healthy male volunteers performed maximal exercise tests on a bicycle ergometer. A control reading was obtained; at a second session propranolol 80 mg was given, and then placebo, 100 mg or 200 mg AQ-A 39 were administered in a randomised double-blind manner. At peak exercise, the heart rate averaged 191.6 beats/min during the control test, 185.8 beats/min after placebo, 172.4 beats/min with 100 mg of AQ-A 39 (-10%), 166.0 (beats/min) with 200 mg of AQ-A 39 (-13.4%); with 80 mg of propranolol, the heart rate averaged 132.8 beats/min and the workload accomplished was substantially lower than that accomplished with AQ-A 39 and placebo which remained the same as in the control test. No effect on blood pressure was observed. The rate pressure product was significantly reduced with AQ-A 39.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Braunwald E. Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol. 1971 Apr;27(4):416–432. doi: 10.1016/0002-9149(71)90439-5. [DOI] [PubMed] [Google Scholar]
- Dämmgen J., Kadatz R., Diederen W. Cardiovascular actions of 5,6-dimethoxy-2-(3-[(alpha-(3,4-dimethoxy) phenylethyl)-methylamino] propyl) phthalimidine (AQ-A 39), a specific bradycardic agent. Arzneimittelforschung. 1981;31(4):666–670. [PubMed] [Google Scholar]
- Harron D. W., Jady K., Riddell J. G., Shanks R. G. Effects of alinidine, a novel bradycardic agent, on heart rate and blood pressure in man. J Cardiovasc Pharmacol. 1982 Mar-Apr;4(2):213–220. doi: 10.1097/00005344-198203000-00008. [DOI] [PubMed] [Google Scholar]
- Harron D. W., Riddell J. G., Shanks R. G. Alinidine reduces heart-rate without blockade of beta-adrenoceptors. Lancet. 1981 Feb 14;1(8216):351–353. doi: 10.1016/s0140-6736(81)91672-x. [DOI] [PubMed] [Google Scholar]
- Hohnloser S., Weirich J., Homburger H., Antoni H. Electrophysiological studies on effects of AQ-A 39 in the isolated guinea pig heart and myocardial preparations. Arzneimittelforschung. 1982;32(7):730–734. [PubMed] [Google Scholar]
- Kobinger W., Lillie C. AQ-A 39 (5,6-dimethoxy-2-[3[[alpha-(3,4-dimethoxy)-phenylethyl]methylamino]propyl]phtalimidine), a specific bradycardic agent with direct action on the heart. Eur J Pharmacol. 1981 Jun 19;72(2-3):153–164. doi: 10.1016/0014-2999(81)90270-3. [DOI] [PubMed] [Google Scholar]
- Lillie C., Kobinger W. Comparison of the bradycardic effects of alinidine (St 567), AQ-A 39 and verapamil on guinea-pig sinoatrial node superfused with different Ca2+ and NaCl solutions. Eur J Pharmacol. 1983 Jan 28;87(1):25–33. doi: 10.1016/0014-2999(83)90046-8. [DOI] [PubMed] [Google Scholar]
- Nicholls D. P., Harron D. W., Shanks R. G. Cardiovascular effects of alinidine and propranolol alone and in combination with hydralazine in normal man. Br J Clin Pharmacol. 1983 Jan;15(1):21–29. doi: 10.1111/j.1365-2125.1983.tb01458.x. [DOI] [PMC free article] [PubMed] [Google Scholar]