Abstract
The kinetics of clobazam taken 3 h before, during, and 3 h after a standard hospital meal were studied in six healthy volunteers. Peak plasma levels were significantly lower when the drug was taken with or after meals suggesting that the rate of absorption was reduced by food. The mean area under the concentration vs time curve was not affected by the time of drug administration indicating that the meal had no effect upon the extent of absorption.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brachet-Liermain A., Jarry C., Faure O., Guyot M., Loiseau P. Liquid chromatography determination of clobazam and its major metabolite N-desmethylclobazam in human plasma. Ther Drug Monit. 1982;4(3):301–305. doi: 10.1097/00007691-198208000-00009. [DOI] [PubMed] [Google Scholar]
- Chapman A. G., Horton R. W., Meldrum B. S. Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. Epilepsia. 1978 Jun;19(3):293–299. doi: 10.1111/j.1528-1157.1978.tb04492.x. [DOI] [PubMed] [Google Scholar]
- Gastaut H. Essai préliminaire d'une benzodiazépine en épileptologie. Nouv Presse Med. 1978 Jul 1;7(27):2400–2400. [PubMed] [Google Scholar]
- Gastaut H., Low M. D. Antiepileptic properties of clobazam, a 1-5 benzodiazepine, in man. Epilepsia. 1979 Aug;20(4):437–446. doi: 10.1111/j.1528-1157.1979.tb04825.x. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J., Allen M. D., MacLaughlin D. S., Harmatz J. S., Shader R. I. Diazepam absorption: effect of antacids and food. Clin Pharmacol Ther. 1978 Nov;24(5):600–609. doi: 10.1002/cpt1978245600. [DOI] [PubMed] [Google Scholar]
- Levy R. H., Cenraud B., Loiseau P., Akbaraly R., Brachet-Liermain A., Guyot M., Gomeni R., Morselli P. L. Meal-dependent absorption of enteric-coated sodium valproate. Epilepsia. 1980 Jun;21(3):273–280. doi: 10.1111/j.1528-1157.1980.tb04073.x. [DOI] [PubMed] [Google Scholar]
- Melander A., Danielson K., Vessman J., Wählin E. Bioavailability of oxazepam: absence of influence of food intake. Acta Pharmacol Toxicol (Copenh) 1977 May;40(5):584–588. [PubMed] [Google Scholar]
- Melander A. Influence of food on the bioavailability of drugs. Clin Pharmacokinet. 1978 Sep-Oct;3(5):337–351. doi: 10.2165/00003088-197803050-00001. [DOI] [PubMed] [Google Scholar]
- Meldrum B. S., Chapman A. G., Horton R. W. Clobazam: anticonvulsant action in animal models of epilepsy [proceedings]. Br J Clin Pharmacol. 1979;7 (Suppl 1):59S–60S. doi: 10.1111/j.1365-2125.1979.tb04666.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rupp W., Badian M., Christ O., Hajdú P., Kulkarni R. D., Taeuber K., Uihlein M., Bender R., Vanderbeke O. Pharmacokinetics of single and multiple doses of clobazam in humans. Br J Clin Pharmacol. 1979;7 (Suppl 1):51S–57S. doi: 10.1111/j.1365-2125.1979.tb04665.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welling P. G. Influence of food and diet on gastrointestinal drug absorption: a review. J Pharmacokinet Biopharm. 1977 Aug;5(4):291–334. doi: 10.1007/BF01061694. [DOI] [PubMed] [Google Scholar]