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. 1976 Feb;3(1):169–175. doi: 10.1111/j.1365-2125.1976.tb00585.x

Renal function, protein binding and pharmacological response to diazoxide.

R M Pearson, A M Breckenridge
PMCID: PMC1428802  PMID: 973937

Abstract

1 The effect of rapid (10s) injections of diazoxide was studied in ten hypertensive patients with varying degrees of impairment of renal function. 2 There was a significant correlation between the patient's plasma urea concentration and reduction in mean arterial blood pressure. Diazoxide was also shown to be less highly protein bound in patients with renal failure. 3 It is suggested that the explanation for the increased hypotensive effect of diazoxide observed in patients with reduced renal function is related to higher unbound drug concentrations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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