Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1976 Feb;3(1):123–134. doi: 10.1111/j.1365-2125.1976.tb00579.x

The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.

M E Pickup, C S May, R Ssendagire, J W Paterson
PMCID: PMC1428819  PMID: 973934

Abstract

1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexanderson B. Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data. Eur J Clin Pharmacol. 1972 Mar;4(2):82–91. doi: 10.1007/BF00562502. [DOI] [PubMed] [Google Scholar]
  2. Gibaldi M., Boyes R. N., Feldman S. Influence of first-pass effect on availability of drugs on oral administration. J Pharm Sci. 1971 Sep;60(9):1338–1340. doi: 10.1002/jps.2600600909. [DOI] [PubMed] [Google Scholar]
  3. Herxheimer H. Ephedrine Dosage in Bronchial Asthma and Emphysema. Br Med J. 1946 Mar 9;1(4444):350–352. [PMC free article] [PubMed] [Google Scholar]
  4. May C. S., Pickup M. E., Paterson J. W. The acute and chronic bronchodilator effects of ephedrine in asthmatic patients. Br J Clin Pharmacol. 1975 Dec;2(6):533–537. doi: 10.1111/j.1365-2125.1975.tb00572.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
  6. Rowland M. Influence of route of administration on drug availability. J Pharm Sci. 1972 Jan;61(1):70–74. doi: 10.1002/jps.2600610111. [DOI] [PubMed] [Google Scholar]
  7. WAGNER J. G. SOME POSSIBLE ERRORS IN THE PLOTTING AND INTERPRETATION OF SEMILOGARITHMIC PLOTS OF BLOOD LEVEL AND URINARY EXCRETION DATA. J Pharm Sci. 1963 Nov;52:1097–1101. doi: 10.1002/jps.2600521116. [DOI] [PubMed] [Google Scholar]
  8. Wagner J. G., Northam J. I., Alway C. D., Carpenter O. S. Blood levels of drug at the equilibrium state after multiple dosing. Nature. 1965 Sep 18;207(5003):1301–1302. doi: 10.1038/2071301a0. [DOI] [PubMed] [Google Scholar]
  9. Welling P. G., Lee K. P., Patel J. A., Walker J. E., Wagner J. G. Urinary excretion of ephedrine in man without pH control following oral administration of three commercial ephedrine sulfate preparations. J Pharm Sci. 1971 Nov;60(11):1629–1634. doi: 10.1002/jps.2600601107. [DOI] [PubMed] [Google Scholar]
  10. Wilkinson G. R., Beckett A. H. Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output. J Pharmacol Exp Ther. 1968 Jul;162(1):139–147. [PubMed] [Google Scholar]
  11. Wilkinson G. R., Beckett A. H. Absorption, metabolism, and excretion of the ephedrines in man. II. Pharmacokinetics. J Pharm Sci. 1968 Nov;57(11):1933–1938. doi: 10.1002/jps.2600571122. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES