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. 1977;4(Suppl 3):283S–286S. doi: 10.1111/j.1365-2125.1977.tb04522.x

Beclomethasone dipropionate aerosol in treatment of perennial and seasonal rhinitis

A review of five years' experience

H Morrow Brown, G Storey, F A Jackson
PMCID: PMC1428858  PMID: 337995

Abstract

1 Five years' experience in the use of beclomethasone dipropionate aerosol (BDA) in the treatment of 315 patients with upper respiratory tract allergy is reviewed.

2 A total of 223 patients with perennial rhinitis was treated. In 23, where the nasal allergy had recurred after oral corticosteroid therapy for asthma was withdrawn, BDA was effective in 69% of cases. A similar success rate (68%) was recorded in 169 patients suffering from perennial allergic rhinitis alone, but a satisfactory response was observed in only 45% of 31 patients with nasal polypi.

3 In 92 patients with seasonal allergic rhinitis freedom from symptoms was achieved in 80%.

4 A total of approximately 534 patient-years of treatment has been recorded without any evidence of side-effects either clinically or on nasal biopsy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN H. M. Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum. Lancet. 1958 Dec 13;2(7059):1245–1247. doi: 10.1016/s0140-6736(58)91385-0. [DOI] [PubMed] [Google Scholar]
  2. Blair H., Butler A. G. Intranasal beclomethasone dipropionate in seasonal rhinitis in general practice. Practitioner. 1976 Mar;216(1293):347–351. [PubMed] [Google Scholar]
  3. Brostoff J., Czarny D. Effect of intranasal betamethasone-17-valerate on allergic rhinitis and adrenal function. J Allergy. 1969 Aug;44(2):77–81. doi: 10.1016/0021-8707(69)90003-3. [DOI] [PubMed] [Google Scholar]
  4. Brown H. M. Some aspects of clinical allergy. Br J Clin Pract. 1970 Dec;24(12):513–522. [PubMed] [Google Scholar]
  5. Brown H. M., Storey G. Beclomethasone dipropionate steriod aerosol in treatment of perennial allergic asthma in children. Br Med J. 1973 Jul 21;3(5872):161–164. doi: 10.1136/bmj.3.5872.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brown H. M., Storey G., George W. H. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J. 1972 Mar 4;1(5800):585–590. doi: 10.1136/bmj.1.5800.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Brown H. M., Storey G., Jackson F. A. Beclomethasone dipropionate aerosol in long-term treatment of perennial and seasonal asthma in children and adults: a report of five-and-half years' experience in 600 asthmatic patients. Br J Clin Pharmacol. 1977;4 (Suppl 3):259S–267S. doi: 10.1111/j.1365-2125.1977.tb04517.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brown H. M., Storey G. Treatment of allergy of the respiratory tract with beclomethasone dipropionate steroid aerosol. Postgrad Med J. 1975;51 (Suppl 4):59–64. [PubMed] [Google Scholar]
  9. Czarny D., Brostoff J. Effect of intranasal betamethasone-17-valerate on perennial rhinitis and adrenal function. Lancet. 1968 Jul 27;2(7561):188–190. doi: 10.1016/s0140-6736(68)92621-4. [DOI] [PubMed] [Google Scholar]
  10. Frankland A. W., Walker S. R. A comparison of intranasal betamethasone valerate and sodium cromoglycate in seasonal allergic rhinitis. Clin Allergy. 1975 Sep;5(3):295–300. doi: 10.1111/j.1365-2222.1975.tb01866.x. [DOI] [PubMed] [Google Scholar]
  11. Gibson G. J., Maberly D. J., Lal S., Ali M. M., Butler A. G. Double-blind cross-over trial comparing intranasal beclomethasone dipropionate and placebo in perennial rhinitis. Br Med J. 1974 Nov 30;4(5943):503–504. doi: 10.1136/bmj.4.5943.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hansen I., Mygind N. Local effect of intranasal beclomethasone dipropionate aerosol in perennial rhinitis. Acta Allergol. 1974 Aug;29(4):281–287. doi: 10.1111/j.1398-9995.1974.tb01655.x. [DOI] [PubMed] [Google Scholar]
  13. Harris D. M., Martin L. E., Harrison C., Jack D. The effect of intra-nasal beclomethasone dipropionate on adrenal function. Clin Allergy. 1974 Sep;4(3):291–294. doi: 10.1111/j.1365-2222.1974.tb01387.x. [DOI] [PubMed] [Google Scholar]
  14. Löfkvist T., Svensson G. An open assessment of becotide (beclomethasone dipropionate) nasal spray in seasonal allergic rhinitis. Acta Allergol. 1975 Oct;30(4):227–238. doi: 10.1111/j.1398-9995.1975.tb01345.x. [DOI] [PubMed] [Google Scholar]
  15. Mygind N., Hansen I., Pedersen C. B., Prytz S., Sorensen H. Intranasal beclomethasone dipropionate aerosol in allergic nasal diseases. Postgrad Med J. 1975;51 (Suppl 4):107–110. [PubMed] [Google Scholar]
  16. Mygind N. Local effect of intranasal beclomethasone dipropionate aerosol in hay fever. Br Med J. 1973 Nov 24;4(5890):464–466. doi: 10.1136/bmj.4.5890.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mygind N., Pedersen C. B., Prytz S., Sørensen H. Treatment of nasal polyps with intranasal beclomethasone dipropionate aerosol. Clin Allergy. 1975 Jun;5(2):159–164. doi: 10.1111/j.1365-2222.1975.tb01848.x. [DOI] [PubMed] [Google Scholar]
  18. Mygind N., Prytz S., Sorensen H., Pedersen C. B. Long-term treatment of nasal polyps with beclomethasone dipropionate aerosol. I. Treatment and rationale. Acta Otolaryngol. 1976 Sep-Oct;82(3-4):252–255. doi: 10.3109/00016487609120897. [DOI] [PubMed] [Google Scholar]
  19. Smith J. M., Clegg R. T., Cook N., Butler A. G. Intranasal beclomethasone diproprionate in allergic rhinitis. Br Med J. 1975 May 3;2(5965):255–255. doi: 10.1136/bmj.2.5965.255. [DOI] [PMC free article] [PubMed] [Google Scholar]

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