Abstract
Saline and salbutamol (250 mug, 500 mug, 750 mug, and 1000 mug) injections were administered under double-blind conditions to seven chronic stable asthmatic patients. The response on the respiratory system (FEV1, FVC) and cardiovascular system (pulse rate, blood pressure and ECG) was monitored for 3 hours. Increasing the dose of salbutamol increased the peak and weighted average effects of FEV1 and pulse rate. The optimum dose, a titration of desired increases in FEV1 and undesirable increases in pulse rate, is 500 mug but doses up to 1000 mug may be administered if necessary.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bowman W. C., Nott M. W. Actions of sympathomimetic amines and their antagonists on skeletal muscle. Pharmacol Rev. 1969 Mar;21(1):27–72. [PubMed] [Google Scholar]
- Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cochrane G. M., Clark T. J., Hanan M. E. The role of oral bronchodilator therapy as shown by a comparison between salbutamol and terbutaline. Curr Med Res Opin. 1973;1(9):517–523. doi: 10.1185/03007997309111715. [DOI] [PubMed] [Google Scholar]
- Ingram J., Gaddie J., Skinner C., Palmer K. N. The effect of intramuscular salbutamol in asthmatics. Br J Clin Pharmacol. 1975 Jun;2(3):263–266. doi: 10.1111/j.1365-2125.1975.tb01585.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marlin G. E., Turner P. Intravenous treatment with rimiterol and salbutamol in asthma. Br Med J. 1975 Jun 28;2(5973):715–719. doi: 10.1136/bmj.2.5973.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parker S. S., Choo-Kang Y. F., Cooper E. J., Cameron S. J., Grant I. W. Bronchodilator effect of oral salbutamol in asthmatics treated with corticosteroids. Br Med J. 1971 Oct 16;4(5780):139–142. doi: 10.1136/bmj.4.5780.139. [DOI] [PMC free article] [PubMed] [Google Scholar]