Abstract
The half-life of antipyrine has been estimated from saliva samples in ten subjects by a gas chromatographic method. Half-life, apparent volume of distribution and total body clearance estimated from saliva and plasma concentrations of antipyrine are not significantly different. The concentration of antipyrine in saliva is independent of flow rate within the range expected in healthy subjects in response to mechanical and sapid stimuli. Antipyrine estimation in saliva could facilitate many areas of phaamacokinetic research limited by the difficulty of obtaining serial plasma samples.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Davies D. S., Thorgeirsson S. S., Breckenridge A., Orme M. Interindividual differences in rates of drug oxidation in man. Drug Metab Dispos. 1973 Jan-Feb;1(1):411–417. [PubMed] [Google Scholar]
- Dawes C., Ong B. Y. Circadian rhythms in the flow rate and proportional contribution of parotid to whole saliva volume in man. Arch Oral Biol. 1973 Sep;18(9):1145–1153. doi: 10.1016/0003-9969(73)90088-5. [DOI] [PubMed] [Google Scholar]
- Graham G., Rowland M. Application of salivary salicylate data to biopharmaceutical studies of salicylates. J Pharm Sci. 1972 Aug;61(8):1219–1222. doi: 10.1002/jps.2600610810. [DOI] [PubMed] [Google Scholar]
- KILLMANN S. A., THAYSEN J. H. The permeability of the human parotid gland to a series of sulfonamide compounds, para-aminohippurate and inulin. Scand J Clin Lab Invest. 1955;7(1):86–91. doi: 10.3109/00365515509134102. [DOI] [PubMed] [Google Scholar]
- Koysooko R., Ellis E. F., Levy G. Relationship between theophylline concentration in plasma and saliva of man. Clin Pharmacol Ther. 1974 May;15(5):454–460. doi: 10.1002/cpt1974155454. [DOI] [PubMed] [Google Scholar]
- Lindgren S., Collste P., Norlander B., Sjöqvist F. Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers. Eur J Clin Pharmacol. 1974 Aug 23;7(5):381–385. doi: 10.1007/BF00558211. [DOI] [PubMed] [Google Scholar]
- Matin S. B., Wan S. H., Karam J. H. Pharmacokinetics of tolbutamide: prediction by concentration in saliva. Clin Pharmacol Ther. 1974 Dec;16(6):1052–1058. doi: 10.1002/cpt19741661052. [DOI] [PubMed] [Google Scholar]