Abstract
1 The antiepileptic activity of oral frusemide (120 mg daily) was compared with that of an identical placebo in a double-blind crossover trial in fourteen patients with severe focal epilepsy who were receiving long-term therapy with established antiepileptic drugs.
2 A statistically significant reduction in the frequency of focal fits was seen with the active drug.
3 Marked drowsiness occurred in three patients during frusemide therapy, causing their withdrawal from the trial.
4 A slight, but significant, rise in serum phenobarbitone concentrations was observed during frusemide therapy, but no change was seen in serum primidone or phenytoin concentrations.
5 Frusemide significantly lowered plasma sodium and potassium concentrations, and increased plasma bicarbonate.
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Selected References
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